Recombinant DNA Research, Volume 4U.S. Department of Health and Human Services, Public Health Service, National Institutes of Health, 1978 - DNA |
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Page 9
... genes is awkward . The best defective adenovirus vector system available is one where the transforming region of Ad2 or 5 is deleted ( making this an absolutely defective virus and a non - pathogen ) and the foreign DNA substituted at ...
... genes is awkward . The best defective adenovirus vector system available is one where the transforming region of Ad2 or 5 is deleted ( making this an absolutely defective virus and a non - pathogen ) and the foreign DNA substituted at ...
Page 18
... genes . I was also glad to see , in section III - C - 2 , that the silly business about using insect viruses as vectors for other DNA segments was removed . The section as written is now appropriate . IV . Roles and responsibilities . I ...
... genes . I was also glad to see , in section III - C - 2 , that the silly business about using insect viruses as vectors for other DNA segments was removed . The section as written is now appropriate . IV . Roles and responsibilities . I ...
Page 24
... genes with E. coli Dear Dr. Fredrickson : I have just received a copy of Bert Ely's manuscript which he has submitted to Genetics for publication . This manuscript amply demonstrates the transfer of chromosomal genes between E. coli and ...
... genes with E. coli Dear Dr. Fredrickson : I have just received a copy of Bert Ely's manuscript which he has submitted to Genetics for publication . This manuscript amply demonstrates the transfer of chromosomal genes between E. coli and ...
Page 28
... genes ( i.e. , that intervening sequences interrupt coding portions of genes ) , the possibility of genes of higher organisms being expressed in procaryotic hosts is greatly reduced . It appears that nature has already provided a more ...
... genes ( i.e. , that intervening sequences interrupt coding portions of genes ) , the possibility of genes of higher organisms being expressed in procaryotic hosts is greatly reduced . It appears that nature has already provided a more ...
Page 34
... GENETICS . In this manuscript , I present data demonstrating exchange of chromosomal genes between E. coli andl Caulobacter crescentus ( p.9 ) . This exchange proceeds in either direction and is dependent upon the presence of a drug ...
... GENETICS . In this manuscript , I present data demonstrating exchange of chromosomal genes between E. coli andl Caulobacter crescentus ( p.9 ) . This exchange proceeds in either direction and is dependent upon the presence of a drug ...
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Common terms and phrases
agencies Appendix approval bacterial biohazards biological containment biological safety certification cloning compliance concern containment levels Dear Dr decisions defendants Department of Health Director National Institutes DNA Advisory Committee DNA Research Guidelines Donald Fredrickson environment Environmental Impact Statement eukaryotic exchange exemptions experimental Falmouth Federal Register Fredrickson Director National funded genes genetic Guidelines for Recombinant hazards Health Bethesda host host-vector systems IBC's infections Institutes of Health involved Jonathan King July 28 laboratory M.D. Dr Maryland 20014 Dear NEPA NIH Guidelines ORDA organisms paragraph pathogens physical containment plasmid potential PRG-NIH procedures prohibition projects prokaryotic proposed guidelines Proposed Revised Guidelines Public Health Service recombinant DNA activities recombinant DNA experiments recombinant DNA molecules recombinant DNA research recommendations regulations responsibility risk assessment Science scientific scientists Section September September 13 September 22 Sincerely specific strains Stuart Newman Ti plasmid vectors viral virus viruses
Popular passages
Page 34 - The Surgeon General shall conduct in the Service, and encourage, cooperate with, and render assistance to other appropriate public authorities, scientific institutions, and scientists in the conduct of, and promote the coordination of, research, investigations, experiments, demonstrations, and studies relating to the causes, diagnosis, treatment, control, and prevention of physical and mental diseases and impairments of man, including water purification, sewage treatment, and pollution of lakes and...
Page 18 - Government shall (A) utilize a systematic, interdisciplinary approach which will insure the integrated use of the natural and social sciences and the environmental design arts in planning and in decisionmaking which may have an impact on man's environment...
Page 26 - ... agency and includes the approval or prescription for the future of rates, wages, corporate or financial structures or reorganizations thereof, prices, facilities, appliances, services or allowances therefor or of valuations, costs, or accounting, or practices bearing upon any of the foregoing. "Rule making" means agency process for the formulation, amendment, or repeal of a rule.
Page 27 - ... when the agency for good cause finds (and incorporates the finding and a brief statement of reasons therefor in the rules issued) that notice and public procedure thereon are impracticable, unnecessary, or contrary to the public interest.
Page 27 - The required publication or service of a substantive rule shall be made not less than 30 days before its effective date...
Page 26 - ... means the whole or a part of an agency statement of general or particular applicability and future effect designed to implement, interpret, or prescribe law or policy...
Page 27 - When rules are required by statute to be made on the record after opportunity for an agency hearing, sections 556 and 557 of this title apply instead of this subsection.
Page 34 - Make grants-in-aid to universities, hospitals, laboratories, and other public or private institutions, and to individuals for such research projects as are recommended by the National Advisory Health Council, or, with respect to cancer, recommended by the National Advisory Cancer Council...
Page 27 - After notice required by this section, the agency shall afford interested persons an opportunity to participate in the rule making through submission of written data, views, or arguments...
Page 26 - The notice shall include — (1) a statement of the time, place, and nature of public rule making proceedings; (2) reference to the...