False Hope : Bone Marrow Transplantation for Breast Cancer: Bone Marrow Transplantation for Breast Cancer (Google eBook)
Arlington Richard A. Rettig Adjunct Senior Social Scientist RAND Corporation, Virginia, Center for Law Peter D. Jacobson Director, Ethics and Health University of Michigan School of Public Health Ann Arbor, Cynthia M. Farquhar M.D. Postgraduate Professor of Obstetrics and Gynaecology University of Auckland, Wade M. Aubry M.D. Associate Clinical Professor of Medicine UCSF Institute for Health Policy Studies
Oxford University Press, USA, Jan 12, 2007 - Medical - 368 pages
In the late 1980s, a promising new treatment for breast cancer emerged: high-dose chemotherapy with autologous bone marrow transplantation or HDC/ABMT. By the 1990s, it had burst upon the oncology scene and disseminated rapidly before having been carefully evaluated. By the time published studies showed that the procedure was ineffective, more than 30,000 women had received the treatment, shortening their lives and adding to their suffering. This book tells of the rise and demise of HDC/ABMT for metastatic and early stage breast cancer, and fully explores the story's implications, which go well beyond the immediate procedure, and beyond breast cancer, to how we in the United States evaluate other medical procedures, especially life-saving ones. It details how the factors that drove clinical use--patient demand, physician enthusiasm, media reporting, litigation, economic exploitation, and legislative and administrative mandates--converged to propel the procedure forward despite a lack of proven clinical effectiveness. It also analyzes the limited effect of technology assessments before randomized clinical trials evaluated decisively the procedure and the ramifications of this system on healthcare today. Sections of the book consider the initial conditions surrounding the emergence of the new breast cancer treatment, the drivers of clinical use, and the struggle for evidence-based medicine. A concluding section considers the significance of the story for our healthcare system.
What people are saying - Write a review
We haven't found any reviews in the usual places.
ABMT ABMTR adjuvant Antman argued ASCO audit autologous bone marrow BCBSA benefit Bezwoda bone marrow transplantation breast cancer patients CALGB CalPERS cancer centers Cancer Institute cancer treatment chapter chemotherapy with BMT Clinical Oncology contract conventional treatment court cyclophosphamide defense attorney denial disease dose chemotherapy drugs ECRI effectiveness enrolled ERISA evaluation evidence experimental treatment federal HDC/ABMT for breast HDC/ABMT procedure health insurers health plans HealthNet Henderson high-dose chemotherapy high-risk breast cancer Hospital informed consent interviews involved issue leukemia litigation lymph nodes mandate McGivney medical procedures medicine metastatic breast cancer National Cancer Institute oncologists Oncology outcomes overall survival participate patient care costs Peters phase 2 studies phase 3 trials plaintiffs protocol randomized clinical trials randomized trials regimen reported response scientific stem cell story Supp technology assessment toxicity treatment for breast tumor Weiss women’s health