Liver RegenerationDieter Häussinger understanding the mechanisms involved in liver regeneration is of crucial importance for clinical medicine, not only regarding carcinogenesis and diabetes treatment, but also for the use of stem cells for cell therapy and liver surgery. This graduate-level text provides an overview of the current state of knowledge of the molecular mechanisms of liver regeneration. Hepatic stem cells are introduced and the important players involved in regeneration such as oval cells, bone marrow and stellate cells are reviewed. The cell signaling pathways that initiate liver regeneration and regulate the switch between proliferation and apoptosis are presented and the role of liver stem cells in tumorigenesis is discussed. The book also treats the epigenetic regulation of liver stem cells and the roles of inflammation and angiogenesis in liver regeneration. This compact overview of the fascinating regenerative capacity of the liver will be of interest to graduate students and post-docs in molecular biology, biochemistry and medicine. |
Contents
| 1 | |
2 Oval Cells Bone Marrow and Liver Regeneration | 17 |
3 Inflammation and Liver Regeneration | 39 |
4 Lymphotoxin ? Receptor and Tumor Necrosis Factor Receptor p55 in Liver Regeneration | 53 |
5 The Hepatic Stem Cell Niches | 63 |
6 Stellate Cells in the Regenerating Liver | 85 |
7 Epigenetics during Liver Regeneration | 99 |
8 Hedgehog Signaling and Liver Regeneration | 111 |
9 EGFR CD95 and the Switch between Proliferation and Apoptosis in Hepatic Stellate Cells ... | 129 |
10 Angiogenesis and Liver Regeneration | 145 |
11 A Quantitative Mathematical Modeling Approach to Liver Regeneration | 159 |
12 Animal Models for Studies on Liver Regeneration | 175 |
13 Therapeutic Potential of Bone Marrow Stem Cells in Liver Surgery | 191 |
| 207 | |
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Common terms and phrases
angiogenesis apoptosis basal lamina bile acids bile duct binding Biol BMSC bone marrow cell types cholangiocytes cirrhosis cytokines Diehl differentiation DNA methylation EGFR EGFR activation epigenetic Fausto fibrosis Figure function G-CSF Gastroenterology gene expression Häussinger Hedgehog signaling hematopoietic SCs hematopoietic stem cells hepatic stellate cells hepatocyte growth factor hepatocyte proliferation Hepatol Hepatology Hh ligands Hh signaling histone human induce inflammatory inhibition kinase Kordes Kupffer cells ligands liver cells liver disease liver injury liver mass liver regeneration liver stem cells lobule macrophages markers mechanisms mediators membrane mice Michalopoulos myofibroblastic Nestin NK cells Omenetti oval cells partial hepatectomy patients phenotype phosphorylation Physiol portal field progenitor cells protein rat liver regeneration after partial regenerative regulation Reinehr resection response role Sawitza signaling pathway Smad Sonic hedgehog space of Dissé stem cell niche stem/progenitor cells surgery tion transcription factor transgenic transplantation tumor necrosis vascular Wang Wnt signaling