Biostatistical Methods in Epidemiology

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John Wiley & Sons, Apr 11, 2003 - Medical - 408 pages
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An introduction to classical biostatistical methods in epidemiology

Biostatistical Methods in Epidemiology provides an introduction to a wide range of methods used to analyze epidemiologic data, with a focus on nonregression techniques. The text includes an extensive discussion of measurement issues in epidemiology, especially confounding. Maximum likelihood, Mantel-Haenszel, and weighted least squares methods are presented for the analysis of closed cohort and case-control data. Kaplan-Meier and Poisson methods are described for the analysis of censored survival data. A justification for using odds ratio methods in case-control studies is provided. Standardization of rates is discussed and the construction of ordinary, multiple decrement and cause-deleted life tables is outlined. Sample size formulas are given for a range of epidemiologic study designs. The text ends with a brief overview of logistic and Cox regression. Other highlights include:

  • Many worked examples based on actual data
  • Discussion of exact methods
  • Recommendations for preferred methods
  • Extensive appendices and references

Biostatistical Methods in Epidemiology provides an excellent introduction to the subject for students, while also serving as a comprehensive reference for epidemiologists and other health professionals.
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Contents

1 Introduction
1
2 Measurement Issues in Epidemiology
31
3 Binomial Methods for Single Sample Closed Cohort Data
77
4 Odds Ratio Methods for Unstratified Closed Cohort Data
89
5 Odds Ratio Methods for Stratified Closed Cohort Data
119
6 Risk Ratio Methods for Closed Cohort Data
143
7 Risk Difference Methods for Closed Cohort Data
151
8 Survival Analysis
159
14 Sample Size and Power
281
15 Logistic Regression and Cox Regression
295
Appendix A Odds Ratio Inequality
307
Appendix B Maximum Likelihood Theory
311
Appendix C Hypergeometric and Conditional Poisson Distributions
325
Appendix D Quadratic Equation for the Odds Ratio
329
Appendix E Matrix Identities and Inequalities
331
Appendix F Survival Analysis and Life Tables
339

9 KaplanMeier and Actuarial Methods for Censored Survival Data
171
10 Poisson Methods for Censored Survival Data
193
11 Odds Ratio Methods for CaseControl Data
229
12 Standardized Rates and AgePeriodCohort Analysis
249
13 Life Tables
263
Appendix G Confounding in Open Cohort and CaseControl Studies
343
Appendix H Odds Ratio Estimate in a Matched CaseControl Study
353
References
359
Index
377
Copyright

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Page 373 - University Group Diabetes Program: A study of the effects of hypoglycemic agents on vascular complications in patients with adult -onset diabetes: I. Design, methods and baseline results, Diabetes 19 (suppl. 2):747-783, 1970; II. Mortality results, Diabetes 19 (suppl. 2): 789-830, 1970. University Group Diabetes Program: Effects of hypoglycemic agents on vascular complications in patients with adult-onset diabetes.

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About the author (2003)

STEPHEN C. NEWMAN, MD, MSc, is Professor of Psychiatry at the University of Alberta, Canada.

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